Tag Archives: brown fat

Thermogenesis Weight Loss

What is it exactly with thermogenesis weight loss?
You see these words together on many sites that promote fat burning supplements. What’s the difference with metabolism? I have also noticed a new trend about “cold thermogenesis” which seems confusing: thermogenesis is all about heat production, so, “cold thermogenesis”, hmm, really??

Do you know what Seth Meyers would say? It’s time for a closer look πŸ™‚

In my last two posts, “Metabolism and Weight Loss” and “Fast Metabolism with Ephedrine“, we have seen that it was possible to raise your metabolism in order to burn more calories. Next to that, I have been asked about the difference between metabolism and thermogenesis: what is thermogenesis weight loss exactly? How does it work? Is it effective? And if so, how to increase your thermogenesis?

Thermogenesis Medical Definition

So what is thermogenesis from a medical point of view? It is literally the Β« creation of heat Β» by the body, in fact a complex biochemical process that we will simplify here. Depending on what is triggering this heat production we will classify it as

  • Exercise Associated Thermogenesis when linked to intentional movement,
  • Non Exercise Activity Thermogenesis when heat is produced by uncontrolled activation of muscles, typically shivering,
  • and finally DIT for Diet-Induced Thermogenesis, which is the production of heat during all processes which follow food intake, or to be specific it is the increase in energy expenditure above the Basal Metabolic Rate divided by the energy of the food intake.

Metabolism and Thermogenesis

Here is how thermogenesis and metabolism relate: your daily energy expenditure depends on your BMR (Basal Metabolic Rate), the energy cost of your physical activity plus your Diet-Induced Thermogenesis.
In these three functions, energy is used and heat is produced, thus thermogenesis is involved.

  • When you sleep, you still need energy to maintain your vital organs (BMR) thus thermogenesis.
  • When you have eaten, you need energy to deal with this food intake and calories will be converted to heat instead of fat thus thermogenesis.
  • Finally, when you move all day long, of course your muscle need energy and produce heat, again thermogenesis.Thermogenesis is an important component of your metabolic rate as it will determine your energy expenditure.

I really want to make it clear for you, because I see so many people confusing thermogenesis and metabolism. I have tried to explain it in easy words in my last post, so I will quote myself here πŸ™‚

Thermogenesis is the consequence and metabolism is the cause.

Here is the best picture that comes to my mind when explaining it: if your body was a house with a nice fireplace inside, metabolism would be the number of wood logs required to keep your house warm, and thermogenesis would be the fire burning the logs and producing heat.

I hope I made it clear and that you see the difference between metabolism and thermogenesis weight loss now. If not, let’s try with a video! This one is really cool because it explains a lot with analogies (glucose and money), maybe a bit long, but if you have the patience you won’t regret it:

Brown Fat or Cold Thermogenesis

Cold Thermogenesis Weight LossI will not detail how thermogenesis works at cellular level, you would be bored πŸ™‚ But still I would like to take this opportunity to explain the following biological processes because they are very important to life:

  • Brown adipose tissue: it’s where thermogenesis usually occurs, babies have a lot of this brown fat and then it reduces. Bad luck πŸ™ That’s why so many sites speak of “cold thermogenesis weight loss” currently. I have explained it in this post, but I didn’t expect these funny reactions here. Don’t miss this one πŸ™‚
  • Mitochondria: these “power plants” are subunits of our cells, specialized in the production of energy (adenosine triphosphate or ATP)
  • In a nutshell: some substances such as free fatty acids go through the mitochondrial energy process but for chemical reasons, heat is produced instead of ATP, which would have resulted in energy storage. To simplify: through thermogenesis, energy (heat) has been dissipated instead of being stocked (fat).

Thermogenesis Weight Loss

You can now easily deduct how thermogenesis can help weight loss: increasing thermogenesis would mean more energy expenditure and less fat storage.

Nice, but how could you achieve that?

There are several ways to increase thermogenesis:

  • Stimulation of some regulating hormones like norepinephrine (noradrenaline, a neurotransmitter described in our page about ephedrine) and leptin (see our article about appetite and prescription drugs for weight loss)
  • Intake of thermogenic products, such as caffeine, capsaicin found in red hot peppers, green tea (catechins), garcinia cambogia (hydroxycitric acid HCA), dioscorea villosa (Wild Yam), bitter orange (synephrine), guarana (guaranine)
  • Increase of Diet-Induced Thermogenesis through low-protein diets, emphasizing celery, garlic, parsley, ginger, cinnamon, turmeric, hot peppers, fishes like salmon or tuna, and green tea of course. Other diets insist on low glycemic foods: seeds, nuts, brown rice, eggs, chicken breast, cheese, fruits and vegetables.

Thermogenesis and Ephedrine

Let’s sum it up. More thermogenesis means less fat storage, for sure. Thermogenesis and metabolism walk hand in hand, raising them will help your weight loss. But if you want serious results, don’t put your hopes on pills that focus on thermogenesis only. Except if you’re ready to wait for years to see some effects πŸ™‚

I have started this blog more than 5 years ago and the best way and quickest to lose weight is still the same: ephedra alkaloids or ephedrine, either alone or stacked with caffeine. You know, this famous combination called EC stack (E for Ephedrine and C for Caffeine) which has synergistic effects, meaning that the effects of both products taken together is higher than the effects of each products taken separately). Ephedrine is by far the best way to boost your metabolism and your thermogenesis. Add a smart diet and some exercise to an EC stack and you will lose weight as humanly possible.

So don’t be distracted by the new “magic pill”, I understand that these marketing people try regularly new angles to sell you weight loss pills, but again, nothing, not even prescription pills can beat ephedrine plus caffeine if you do it right, in all legality and safety, as explained everywhere in this site.

-Mike Budd

Copyright http://ephedrinewheretobuy.com

Inspired by Brown Fat and Cold Weather

Some of you guys are not serious πŸ˜‰

Do you remember that we published recently the results of a medical study comparing the weight loss results of ephedrine and brown fat activated by cold exposure?
If not, it is still time to have a look, you will probably be amazed by these findings.

Well, serious as we are, we did not plan that you would make fun of this serious medical survey πŸ˜‰

In fact we didn’t expect so much creativity about losing weight in cold weather!
Not speaking of questions about the “paradox of fat Inuit women” πŸ˜‰
Not even mentioning Alaska in general and Sarah Palin in particular – you know how politically correct we are πŸ˜‰

Your emails made us laugh a lot and honestly, it’s a pity that laughing doesn’t burn fat, I would be skinny now πŸ˜‰

Some emails came with pictures, but I will share only two of them – probably the only ones I can decently upload without being categorized as an adult site πŸ˜‰

Here we go:

Your feedback about ephedrine compared to brown fat for weight loss

 

 

 

 

 

 

 

And also:

Second feedback about ephedrine compared to brown fat for weight loss

 

 

 

 

 

 

 

Seriously πŸ˜‰

While waiting for winter and snow, you can always purchase ephedrine here.

Thanks for your feedback and keep in touch!

Mike Budd.

Β© 2011-2013 Ephedrine, Where To Buy? All rights reserved.
Copyright http://ephedrinewheretobuy.com

Brown Fat Compared to Ephedrine for Weight Loss

A recent survey [1] focusing on weight loss has drawn attention on ephedrine: a research team at Joslin Diabetes Center have tried to find new ways to activate brown fat and thought that ephedrine might be a potential triggering agent, due to its known effects on the sympathetic nervous system, such as the famous “fight or flight response“.

Before going to the conclusion of this study, it might be useful to give some basic information about brown fat and how it can lead to weight loss.

What is brown fat?

Brown fat is the common name for Brown Adipose Tissue (BAT), also known as “good fat”. Brown fat has been initially classified as an adipose tissue because of it is storing lipids, but recent findings showed that it is in fact closer to muscle than to white adipose tissue. The main function of brown fat is to produce heat in a process called non-shivering thermogenesis. The exceptional thermogenic characteristics are due to the high number of mitochondria which are specialized cells transforming fatty acids into energy and heat.

How does brown fat work?

Brown fat is linked to the brain by the sympathetic nervous system and activated through the release of norepinephrine. Then a complex chemical process begins: triglyceride breakdown, release of fatty acids which enter the mitochondria and are degraded through ß-oxidation, followed by CAC (citric acid cycle) and activation of UCP1, a protein uncoupling mitochondrial respiration from ATP, producing heat. To make it easy: the activity of brown fat is regulated by the brain through the sympathetic nervous system in case heat is needed for body temperature control.

Where is brown fat located in the body?

Unlike white fat which is usually located in hips, belly etc (android and gynoid fat), brown fat is mainly found in the neck and below the clavicles, but this may vary a lot depending on age, gender, weight, etc.

Do adults have brown fat?

Until recently, the scientific community was convinced that brown fat was present in newborns only. In the 1990s, PET scans of cancer patients showed unexpected areas of tissues with a high glucose uptake. Unfortunately this finding found no echo outside of the radiology profession and only in 2002 the link with brown adipose tissue has been envisaged. At this time, the common belief was that brown fat was to be found in only 2 to 5% of adults. Further research has proved that at least 30% of all adults possess brown fat and probably 100% of young adults.

Ephedrine compared to Brown Fat Cold ActivationWhy is it interesting?

Brown fat is drawing attention because of potential weight loss effects: we know since the research conducted by Ouellet et al [2] that brown adipose tissue in adults is burning fat actively when stimulated by cold exposure, through the combustion of stored lipids within brown fat in the initial phase and in case of prolonged thermogenesis, through the combustion of the components of ingested food, involving gut and liver. As brown fat burns calories to generate heat for defense against cold, it became interesting to the weight loss industry:

  • A first approach is to work on metabolic pathways which make white fat cells act like brown fat cells and enable them to release energy as heat [3].
  • A second approach is to work on the activation of brown fat: to the current knowledge this is only possible during cold exposure, the idea is thus to identify agents which have the same pathways and mimic cold in brown activation.

How does it relate to ephedrine?

There are two links: the first one is that brown fat is triggered by the sympathetic nervous system through the release of norepinephrine, which is very close to the physiological effects of ephedrine and that is why many researchers thought that ephedrine might be a good candidate of brown fat metabolic activation. The second reason why ephedrine has been compared separately to brown fat effects is that ephedrine is considered as one of the most effective fat burner, therefore it has been used as a reference to measure the weight loss results obtained through brown fat activation alone.

What protocol has been used for this study?

The study conducted by the Joslin team has tested ten healthy adults in three ways:

  • injections of ephedrine
  • injections of a control saline solution (placebo)
  • wearing water-cooled 57F (14C) vests for two hours

Each intervention was followed by PET/CT scans in order to measure the consequent brown fat activity.

What are the results of this survey?

The main findings are the following:

  • Ephedrine did not turn on brown fat: there was no difference in BAT activity compared to placebo injections.
  • Cold exposure did stimulate brown fat energy expenditure significantly.
  • Ephedrine and brown fat activity have different sympathetic pathways: both increased blood pressure and energy expenditure, but ephedrine raised also heart rate and the circulation of various metabolites (insulin, glucose, thyroid hormones) when cold brown fat activation decreased heart rate and had few effects on metabolites.
  • Regarding weight loss effects, ephedrine and brown fat activation resulted in the same number of calories burned during both programs.

Conclusion

According to the researchers, brown fat activation is promising because it can achieve the same weight loss results as ephedrine with less systemic effects. Another study is already planned with subjects wearing water-cooled vests for several weeks. More research will tell if weight loss resulting from brown fat stimulation can be reasonably achieved through cold, or if the pharmaceutical industry should try to identify other agents that would mimic cold activation of brown fat. For sure, wearing cooling vests for a long time would be very uncomfortable and overweight people are probably not ready to accept such discomfort.

Of course researchers show enthusiasm for their findings when they might help combat obesity, knowing the financial attractiveness of the weight loss market. Most experts think that no magic pill will come from the current pharmaceutical research for the next ten years. Any discovery in the weight loss field sets off fireworks in the industry, and this has also been the case when this study has been published.

According to Dr Aaron Cypess, lead author of this survey: β€œThe problem with prescribing ephedrine is that people need to stay healthy their whole lives. Are we really going to be prescribing a sympathetic activating drug for someone’s entire life? There need to be safer, long-term solutions“.

We don’t agree with this point of view. Of course people need to stay healthy, but overweight people (no even speaking of obese people) have to get healthy again before staying healthy! Ephedrine can help them in countries where sales are authorized for weight loss, due to its synergetic effects on appetite, metabolism, energy and lean muscle mass retention: ephedrine will help shed the pounds when they are not able to lose weight without a physiological boost at start. The idea is not to buy ephedrine for years, but to burn fat rapidly and to keep it off definitely without drug support, by a change in lifestyle, such as eating better and being more active. As a comparison, many smokers stopped definitely only with the initial support of nicotine patches. Do they have to use nicotine patches for the rest of their life? Of course not. The same applies to weight loss obtained through initial support of ephedrine.

References

[1] Cypess A, et al. Cold but not sympathomimetics activates human brown adipose tissue in vivo, PNAS USA Early Edition 10.1073/pnas.1207911109

[2] Ouellet V, et al. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest. 2012;122(2):545–552

[3] Plutzky J, et al. Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue, Nature Medicine 18, 918–925 (05/06/2012) 10.1038/nm.2757

By Mike Budd

Β© 2011-2013 Ephedrine, Where To Buy? All rights reserved.
Copyright http://ephedrinewheretobuy.com