Dosage of ephedrine in EC stacks

ECA stack stands for Ephedrine + Caffeine + Aspirin.

In fact, several medical trials have proven that ephedrine had synergistic effects with caffeine and aspirin in terms of weight loss. [1] [2] [3]
How come? Simply because ephedrine works through stimulating the release of norepinephrine…
But in Her Infinite Wisdom, Mother Nature balanced the action of norepinephrine through antagonists, adenosine and synthesis of prostaglandins…
So what? As adenosine and prostaglandins both inhibit the effect of norepinephrine, the brilliant solution is to find a way to reduce their action with antagonists!
This is achieved with:

  • caffeine which opposes the effect of adenosine
  • aspirin which inhibits the synthesis of prostaglandins

thus promoting by their combined effect the release of norepinephrine.
Practically, ECA stack is reduced for safety reasons to an EC stack: experience proved that adding aspirin was of low benefit compared to the risks given the potential dosage errors, so you should put aspirin aside. E+C are enough.

OK, that was the scientific information. Knowing that an EC stack is probably the most effective way to lose weight, here is what people usually ask us for.

WARNING: the recommended dosage presented below is taken from clinical trials (see our page with all references) and also from common practices, the authors assume no liability or responsibility for any direct or indirect consequences of decisions made by third parties to follow or adapt this program. As you can read in several pages here, we truly believe that there are enough medical studies and clinical trials supporting the fact that ephedrine and caffeine present no risk to healthy people if taken at recommended doses and with strict precautions (see remarks below). Yet if you decide to take an ECA stack, it is at your own risk and not ours – our aim is just to give you our best information so that you can make your own informed decisions.

Recommended dosage

Here is our best recommendation based on clinical trials and common usage [4] [5]:

  • Day 1: 10 mg ephedrine + 100 mg caffeine to test hypersensitivity to ephedrine. Fast heart rate is normal, as from having a lot of coffee.
  • From day 2 on: 3 times per day, minimum time between 2 doses is 4 hours, last dose at least 6 hours away from bedtime.
  • Day 2 & 3: all 3 doses are half: 10 mg ephedrine + 100 mg caffeine
  • Day 4 to 7: 1st dose is full: 20 mg ephedrine + 200 mg caffeine, 2nd and 3rd doses are half: 10 mg ephedrine + 100 mg caffeine
  • Day 8 to 14: 1st and 2nd dose are full: 20 mg ephedrine + 200 mg caffeine, 3rd dose is half: 10 mg ephedrine + 100 mg caffeine
  • Day 15 and onward: all 3 doses are full: 20 mg ephedrine + 200 mg caffeine


We have added two pages, giving the day per day dosage for ephedrine 8 mg and caffeine 200 mg, in milligrams and in tabs per serving:

Important remarks:

  • if any sleeping trouble, try last dose 8 hours before bedtime and reduce to 2 doses per day.
  • No additional coffee, tea, cola etc! Drink more than usual
  • After 4 weeks, effects seems to reduce (you have more appetite and less energy) but thermogenesis remains high and so fat loss
  • No more than 8 weeks in a row, then minimum 2 weeks off and then back to Day 2 directly
  • Avoid heat, inside or outside! Very risky
  • No asthma treatment in the same time, high risk of overdose!
  • No cardio above 70% of your max heart rate: (220 minus your age) x 0,7
  • Stop immediately in case of any adverse effects such as high blood pressure, irregular heartbeat, heart palpitations, dizziness (see our page about side effects).

Alternative recommendation:

  • Week 1 to 4: half dose (10 mg ephedrine and 100 mg caffeine) 3 x/day
  • Week 5: full dose (20 mg ephedrine and 200 mg caffeine) 3x/day

All doses should be taken 30 minutes before each meal as it has proven to be more efficient for many people. There is no strict recommendation by doctors if doses should be taken with meals or outside meal time, except in case of stomach irritations: in such cases doses should be taken with each meal.

Now that you know what to buy, the next step is to make sure that you get the good product and not a fake one and that you select an honest seller who will deliver your order! For this reason we have done a review of most shops having real ephedrine for sale online, don’t miss it before any purchase!

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By Mike Budd