Monthly Archives: September 2012

Ephedrine For Sale Over the Counter Again?

A few months ago we heard about a true innovation that made us hope for a definitive solution to the major problem of ephedrine and pseudoephedrine, which is their precursor role in the manufacture of methamphetamine: a relatively small drug company, Highland Pharmaceuticals, has set fireworks in the industry by announcing a new formulation process called Tarex™ which can produced “meth-resistant” pseudoephedrine.

How does it work to be meth-resistant?

Chemical structure of methamphetamine on EphedrineWhereToBuy.comThe exploding rise of meth that has overwhelmed part of the Midwest, South and West is partly due to the fact that producing meth is relatively easy, especially with the “shake and bake” or “one pot” method. Meth cooks combine pills of pseudoephedrine with basic chemicals by shaking up the components in a 2-liter soda bottle. This process is very dangerous because the needed chemicals are highly flammable. A key step of the reduction of pseudoephedrine to meth is the crystallization phase when heated. This is where Tarex™ makes the difference: the process is stopped before crystallization can occur, due to the new formulation which turns the chemical solution into a gooey substance. “It kind of gunks up”, Highland Pharmaceuticals says.

Is it confirmed by officials?

Law Enforcement Officer on EphedrineWhereToBuy.comThe Drug Enforcement Administration has been very interested by this product, as it is a new proactive approach of fighting meth compared to classical methods: instead of chasing meth cooks, prevent them cooking meth! Preliminary testing of the Tarex™ process has been done, by using the same extraction method as used by meth makers. The results are positive at this stage and Highland Pharmaceuticals hope for a commercial launch of their product called Zephrex-D in early November, starting with pharmacies in the St. Louis area, close to the drug company’s headquarters.

Will it be sold over the counter?

Could ephedrine could be sold over the counter? More on EphedrineWhereToBuy.comFor the moment, all sales of ephedrine and pseudoephedrine are strictly controlled: some states have passed laws requiring a doctor’s prescription and for the rest, retailers are asking customers to sign a form before purchasing ephedrine-based medications. Those using the NPLEX real-time tracking system even check if the purchased quantity is not exceeding the legal limit, which is a total of 3.6 grams per sale and 7.5 grams per month if delivered per mail or 9 grams if bought locally. Zephrex-D will begin its commercial life behind the counter as all other pseudoephedrine medications, but Highland Pharmaceuticals plans to sell it over the counter as soon as possible: they have already asked the DEA to exempt their product from the CMEA (Combat Methamphetamine Epidemic Act 2005) that forces to sell ephedrine-based medications behind the counter. But this might take time, from 6 months to 3 years, depending on the political treatment that this request will receive. We will come back to that point later.

Conclusion

These are great news, maybe the best since 2004.  Until Highland Pharmaceuticals gets exemption, nothing will change regarding ephedrine for sale online and behind the counter, people suffering from cold, flu, allergies or asthma will not see the difference. But as soon as Zephrex-D will be available in stores shelves, it could be a game changer for ephedrine.

In our next post, we will try to analyze the possible consequences for all concerned people.

Recommended articles

Will politicians authorize meth-resistant ephedrine to be sold over the counter?Ephedrine Sold Over the Counter, A Political Fiction

 

 

Nexafed, another meth-proof ephedrine for sale

New Meth-Proof Ephedrine for Sale

 

 

Mike Budd.

© 2011-2013 Ephedrine, Where To Buy? All rights reserved.
Copyright http://ephedrinewheretobuy.com

Weight Loss With Caffeine or Ephedrine Alone, Compared to an EC Stack

Compared weight loss effects of caffeine, ephedrine and EC stackIf you search the web about the weight loss properties of caffeine, you will be amazed by the number of contradictory results. We will not detail the arguments of both sides, as many are outdated information or lack serious support of medical research. Some articles even publish wrong assessments such as: “The effect of caffeine on blood sugar is unhealthy and the type of problem that leads to insulin resistance – a precursor to type 2 diabetes“. This is proved wrong by the current medical research, as you can see in our in-depth analysis here, or directly through the abstract of the related studies [1] [2] [3].

Weight loss effects of coffee alone

Fascinating Alkaloids, CaffeineFortunately there are also reliable medical sources of information online, including us 😉 and usually their position regarding the fat burning effect of coffee alone is more balanced:

  • Coffee alone can help losing fat moderately, as found in this randomized, placebo-controlled, double blind parallel clinical trial: “High caffeine intake was associated with weight loss through thermogenesis and fat oxidation and with suppressed leptin in women. In habitual low caffeine consumers, the green tea-caffeine mixture improved WM, partly through thermogenesis and fat oxidation[4]. By the way we take this opportunity to remind you that not all medical studies are equal, here we refer to a RCT study that belongs to the interventional type as opposed to observational studies, as explained graphically in our previous post about decaffeinated coffee. In a nutshell: interventional studies give evidence when observational studies measure the probability of risk factors.
  • When we speak about the benefits of coffee for weight loss, we mean black coffee only, not these special drinks with cream or syrups which can easily exceed the average calorie intake of a lunch or dinner.
  • There has been a buzz about green coffee beans which may help losing weight at higher dosage (700 to 1,050 mg of extract), as found in a recent study presented in March 2012 at the National Meeting & Exposition of the American Chemical Society. This findings are interesting but a bit out of our topic (coffee, caffeine and ephedrine) and for sure they deserve further research by the medical community.
  • The current consensus is that overweight people should not rely on coffee alone to lose weight: a moderate consumption will bring many health benefits, but when it comes to cut fat permanently, a few cups of coffee will not do the trick alone, there are other ways that are much more effective to lose weight and keep it off permanently.

Weight loss effects of ephedrine alone

EphedrineWhereToBuy.com Prefers Kaizen Ephedrine HCLThe fat burning properties of ephedrine are well-known, in case you need a refresher you can have a look at our description here. In two words, ephedrine stimulates the central nervous system by increasing the activity of noradrenaline on adrenergic receptors and the result is a kind of adrenaline rush. The main physiological consequences are an increase of your BMR (basal metabolic rate), blood pressure, thermogenesis, fat oxidation, energy level and athletic performance, and a reduced appetite.

How many pounds can you shred within a reasonable period of time? It depends on individual factors, as genes play a big role in the way your body stores and burns fat, but a good indication is given by this official meta-analysis [5] of the “efficacy and safety of ephedra and ephedrine alkaloids for weight loss” that we will just quote here: “Ephedrine was associated with a statistically significant weight loss of 1.3 pounds/month more than was associated with placebo for up to 4 months of use“.

This official meta-analysis had raised many comments by the scientific community, due to the controversy around the FDA ban at this time. For instance the selection of 20 trials out of 44 controlled trials seemed to be not really in favor of ephedrine. We discussed this point several times with friends and our conclusion is that at least these studies are valid, they are RCTs with unquestionable evidence so we take them as they are: proven facts. Thus our conclusion is that ephedrine alone has modest weight loss results. In the next section we will see that it is due to a reaction of your body that limits the effects of ephedrine and that there is a way to circumvent this limit factor.

Weight loss effects of ephedrine and caffeine (EC stack)

This circumventing way of cutting pounds more effectively is to combine caffeine with ephedrine, the so-called EC stack. Before going any further, we would like to remind you that ephedrine has been banned in the USA and some other countries for the usage as dietary supplement: it is still legal to buy ephedrine under a certain limit per month because it is one of the most effective medications for cold, flu, allergy and asthma, but companies are not allowed to promote ephedrine for weight loss.

Legality of ephedrine in Canada The legality in Canada is less restrictive, for instance you can legally buy ephedrine with a limit of 8 milligrams per tab, but it is not permitted to sell EC stacks in one package, you have to purchase ephedrine and caffeine separately. By the way, if you decide to get an EC stack, our strong recommendation is to buy Kaizen Ephedrine HCL 8 mg which is the best for us.

But enough digression: you have all details about the legal aspects of ephedrine in our dedicated blog category. Here we want to focus on the weight loss that can be achieved with an EC stack. Based on medical evidence, ephedrine will have better results than caffeine, but will be less effective alone than associated to caffeine in an EC stack: in fact these two alkaloids will develop a synergy together.

Ephedrine's effect on neurotransmitters Basically, caffeine acts as an inhibitor of adenosine, which is an antagonist of norepiphedrine, which is the chemical agent that triggers the physiological effects of ephedrine. It sounds a bit weird, but it is easy to get it when said in plain words:

  • ephedrine acts on the nervous system because it increases the release of norepiphedrine.
  • but your brain has a moderating function which sees that norepiphedrine has been released and in order to balance it, another chemical agent is released: adenosine. That’s why we say that adenosine is an antagonist of norepiphedrine.
  • The smart idea is: if we can reduce the effect of adenosine, norepiphedrine will not be blocked and thus it will give its full outcome.
  • This is achieved by caffeine, which limits the effects of adenosine and thus maximizes the physiological reaction to ephedrine.
  • In conclusion, caffeine and ephedrine are synergistic products: the weight loss results when both are used in an EC stack is greater than the sum of the results obtained by caffeine alone and ephedrine alone.

The effectiveness of EC stacks or ECA stacks (EC stack plus aspirin, not recommended) has been measured by so many medical studies that the difficulty for us is to select one of them. We have picked up a 9-month, double-blind, randomized control study comparing the efficacy and safety of ephedrine and caffeine versus placebo [6]. Here are the results: “The treatment group lost significantly more body weight (-7.18 kg) and body fat (-5.33 kg) than the control group (-2.25 and -0.99 kg, respectively)“. And the conclusion of the researchers: “A low potency ephedra/caffeine mixture appeared safe and effective in causing loss of weight and body fat, and improving several metabolic parameters, including insulin sensitivity and lipid profiles when tested under physician supervision“.

Conclusion

To sum it up, we will repeat a part of the conclusion of this medical trial: EC stacks are “safe and effective in causing loss of weight and body fat. We have not much to add, except this crucial point: this is true only at normal doses. Make sure to read our recommendation of pages, EC stacks safe dosage and EC stacks standard dosage.

This will be it for this article, because there is still a lot to say: believe it or not , there are other ways even more effective for your weight loss than an EC stack! And also based on synergistic effects.
Stay tuned until we tell you more in our next article. Meanwhile don’t hesitate to email to tell us what you think about our cliffhanger: lame? Be honest, but not too much 😉

References

1. Salazar-Martinez E, Willett WC, et al. “Coffee consumption and risk for type 2 diabetes mellitus“. Ann Intern Med. 2004 Jan 6;140(1):1-8.
2. van Dam RM, Willett WC, et al. “Coffee, caffeine, and risk of type 2 diabetes: a prospective cohort study in younger and middle-aged U.S. women“. Diabetes Care. 2006 Feb;29(2):398-403.
3. Huxley R, Lee CM, et al. “Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysis“. Arch Intern Med. 2009 Dec 14;169(22):2053-63.
4. Westerterp-Plantenga MS, Lejeune MP, Kovacs EM. “Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation“. Obes Res. 2005 Jul;13(7):1195-204.
5. Shekelle PG, Hardy ML, et al. “Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance. A meta-analysis“. JAMA 289:1537-1545, 2003.
6. Hackman RM, Havel PJ, et al. “Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: a randomized controlled trial“. Int J Obes (Lond). 2006 Oct;30(10):1545-56.

Mike Budd.

© 2011-2013 Ephedrine, Where To Buy? All rights reserved.
Copyright http://ephedrinewheretobuy.com

Why Do People Drink Decaffeinated Coffee?

And why do we ask? 😉

Because we saw in our last article that a moderate coffee consumption had more health benefits than drinking decaffeinated coffee: the positive effects of caffeine are added to those of other coffee components such as antioxidants. In other words: do people really know about the health effects of coffee? And if they knew about it, would they still drink decaffeinated coffee?

This raises the question of medical information in general and how people react or change their habits based on that information. Coffee is a good example: it illustrates perfectly what we want to point out.

A brief history of coffee’s image throughout the ages

  • coffee has always been appreciated and it is still one of the most consumed beverage in the world since centuries.
  • On the other hand, coffee always arose suspicion: it is black, strong, it alters the mind and has powerful physiological effects, no surprise then that coffee has always been a usual suspect.
  • Our literature is full of stories and anecdotes about coffee and its dangers, as old as from the 17th century, see for instance the famous “Women’s petition against coffee” in 1674 and how men replied to that .
  • In more modern ages, the scientific population has conducted thousands of studies during decades and has informed essentially about the risks.
  • In the 60s and early 70s, several studies attributed a risk factor of heart disease and bladder cancer to coffee: in the global opinion, drinking coffee became a risky pleasure and decaffeinated coffee developed accordingly.
  • Years later, hundreds of medical studies have been conducted and surprisingly most of them have refuting the previous findings: the relation between coffee consumption and risk of heart diseases or bladder cancer has been denied by several studies, and coffee has even been presented as reducing the risk of other diseases such as liver cancer, type 2 diabetes and neurodegeneration.

So what should people believe? It seems like scientists have been ambivalent on this topic: couldn’t they state once and for all if coffee is good or bad for us?

Why is it so hard for doctors and researchers to take a stand about coffee and health?
As you can guess, doctors are serious people and they don’t communicate widely unless there is a clear evidence proven by scientific studies, submitted to their pairs and approved by the whole community. If there is any doubt or if this medical communication might be misunderstood or harm people, they stay cautious and ask for further researches.
As a consequence, unless scientifically proven, you won’t hear from them that “this is white and this is black”, you will more probably hear about shades of grey.

In the case of coffee and health effects, the ambivalent communication is mainly due to the methodology of these medical studies: they are “observational” and not “interventional”. Let us clarify these methods in a few words.

Observational versus interventional studies

Observational research methods take their name from the fact that the investigator simply observes, no interventions on the studied population are carried out by the investigator. The main categories of observational research are cohort studies, cross-sectional studies and case-control studies.
A picture is worth a thousand words, and you know that knowledge is key 😉 That’s why we took time to do these nice pictures which explain how observational studies are conducted and also one picture for the famous RCT (Randomized Controlled Trial) so that you see the difference.

Cohort study

This type of observational study selects a large number of persons before the condition appears and follow up each subject during years, and then will analyze at the end the probable causes by comparison between people.

EphedrineWhereToBuy.com about observational studies: here the Cohort Study

Cross-sectional study

These studies select subjects at one point in time only (today) without regard to the condition and deduct a risk factor from the look at each subject .

EphedrineWhereToBuy.com about observational studies: here the Cross-Sectional Study

 

Case-control study

This last category of observational research selects only subjects who have the condition, then look back at the history of each subject and then analyze a risk factor by comparing to a group having no condition.

EphedrineWhereToBuy.com about observational studies: here the Case-Control Study

 

Randomized Controlled Trial

We mention this interventional study only to give you an easy comparison to the observational ones.

EphedrineWhereToBuy.com about interventional studies: here the Randomized Controlled Trial

 

Limitations of observational studies

These observational methods are scientifically valid (sample, control group, quality of measurements, distortion) and they are used mainly for the research of risk factors, or when other methods can’t be used for ethical reasons (danger for the subjects) or practical reasons (large scale studies running for decades). Of course the weakness of observational studies, compared to randomized, double-blind, and placebo-controlled clinical trials, is that the researchers deduct a probable risk factor but without unquestionable evidence. With a randomized controlled trial, you get evidence. With an observational study, you get a risk factor and a probability of disease, but no evidence.

Today we know that it is highly probable that coffee has more benefits for human health than harms, but highly probable does not equal 100 percent certainty. Our common sense has then to prevail, in order to act based on the level of probability, if certainty cannot be achieved: each one of us has to assess the strength of the evidence by comparing the risks to the benefits.

To come back to our question: why do so many people drink decaffeinated coffee? Probably not due to a better taste compared to coffee. Either because they want to avoid some effects that they really experimented by themselves (sleep disorder for instance) or because they think that caffeine is bad for them (blood pressure, pregnancy etc.) or simply they are not sure and they apply a precautionary principle.

Here is our own point of view

Based on the in-depth analysis we did recently, we see the balance of risks and benefits of coffee as a Gauss curve (also known as “bell curve”) based on consumption: a few cups will bring positive results until a peak is reached, depending on individual factors, and then after a certain limit the negative effects will be higher than the potential healthy effects. The safe attitude is then to stay under a reasonable limit: in that way you won’t have the maximum benefits but you stay on the safe side. Then the good question is: what is a reasonable consumption for you? Again, it can vary but the usual limit is set to 4 or 5 cups per day.

By the way, did you notice how much this approach about dosage and the resulting risks and benefits balance also apply to another alkaloid, ephedrine? This is a perfect transition to our coming article focusing on weight loss: compared to the fat burn effect of an EC stack, what can you expect from coffee that has been proven medically?

Last words for decaf drinkers: stay informed (but don’t trust all pages on the web), focus on yourself (your body knows), use your common sense… and you will be fine!

Keep in touch,
Mike Budd.

© 2011-2013 Ephedrine, Where To Buy? All rights reserved.
Copyright http://ephedrinewheretobuy.com

Coffee, A True Wonder Drug: The Making Of

Done!

As told in our previous post, Focus on the C of EC stacks: Caffeine, we are proud to publish the first part of our new article: Coffee, A True Wonder Drug?

I know that it may sound like self-satisfaction: it is 😉
You know that feeling, when you finish something and you are truly happy about the result (and about yourself of course). Well, that’s exactly what we feel 🙂

To be honest it has been a real challenge to finish it so quickly, considering the amount of work: the goal was to come to the end of the first part before kids go back to school, you know, this period of the year where you always have to go shopping again and again because there is always something missing in their school supplies 😉

I would like to give you more details about this hard work, not to complain 😉 we do it with real pleasure 😉 but to tell you more about us, how we work and what is our motivation.

Well, the topic was big, this question “is coffee good or bad for you” is quite frequent on the web, but that’s exactly our point: we don’t trust easily what we find online 😉

So here is our approach:

  • We have a workshop where we go around the table quickly so that everyone can give his/her own point of view on this topic.
  • Then open discussion, arguing a bit 😉
  • Then we structure: what part of this topic do we want to develop because useful to our readers? A, B, C, conclusion.
  • Task allocation: this is the difficult part 😉 To be serious, it depends of course on the specialty of each team member, but sometimes we have to vary a bit and adapt to the available resources.
  • Then we work on our own: research and notes.
  • New workshop where everyone is presenting medical studies, risks and benefits: here we discuss again to see to come to our own point of view as a team. The key question is to know is there is enough evidence to present a point as valid, reliable, something that we have personally checked, that we trust and we can publish or even recommend. If some don’t agree, we talk again, we are a democracy 😉
  • Then the writing task itself is divided between us and afterwards commented by all, corrected and finally approved.

Nice process as you can see 😉

The good point is that it helps us to update our own medical knowledge: after sessions like this one, believe me, you can discuss every detail with any expert on earth 😉
And of course we share this knowledge with you. But don’t trust us on words only, as generally the case on the web: you will find so many articles published by people who have no real idea about what they post. In fact those people don’t write articles but just copy them, sometimes with slight changes, other times without, and not even mentioning the author(s) or their source of information.
I don’t say that to be mean, it’s just the way it is…

In our case, you can trust us. Really. If not, we can’t force you  😉 but in that case, please have a look at our article! How clear, how nice with these cool pictures for each condition 😉 I’m kidding, this is just the look of it, not the important part: the heart of this article is in the references. As you can see, for all benefits and risks, we have selected one or several medical studies that you can check on your own: just follow the links into brackets next to each condition and then click on the link that we have included in the footer notes and you will access the official abstract of this medical study (methodology, short summary, findings).

Did you know that there are more than 20,000 medical studies about coffee and health? Well we selected only 40 😉
But for each one, we wanted you to be able to check on your own, just by a click.

I hope that this gives you a better idea of what we mean when we say that we are serious people and that we deserve your trust.
The name we gave us is just for fun (Health Dream Team…), our main topic is quite controversial because it is about ephedrine and where to buy it, but our work here is real, honest and serious. That’s why we are happy when our information can help you, your friends, your beloved ones. We do it a bit for us and a lot for you.

That was it for self-satisfaction 😉 we have the second part of an article to finish now 🙁

Keep in touch,
Mike Budd.

© 2011-2013 Ephedrine, Where To Buy? All rights reserved.
Copyright http://ephedrinewheretobuy.com